Angelica gigas is a PERENNIAL growing to 1.8 m 6ft at a medium rate. It is not frost tender. It is in flower from July to August, and the seeds ripen from August to September. The species is hermaphrodite has both male and female organs and is pollinated by Insects. The plant is self-fertile. Suitable for: light sandy, medium loamy and heavy clay soils. Angelica wasn’t believed to cure the plague but protect against it; a piece of root was held in the mouth as an antiseptic. In Germany, it was known as the root of the holy ghost and was believed to eliminate the effects of intoxication and also to render witchcraft and the evil eye harmless. Angelica gigas, also called Korean angelica, giant angelica, purple parsnip, and dangquai, is a monocarpic biennial or short lived perennial plant from China, Japan and Korea.It inhabits forests, grasslands and banks of streams. The roots are used in traditional Chinese medicine. Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol pyranocoumarin type components have.
Antibacterial coumarins fromAngelica gigas roots. Sanghyun Lee 1,. Kim, N. J., and Kong, Y. Y., Studies on the coumarin constituents of the root ofAngelica gigas Nakai Isolation of decursinol angelate and assay of decursinol angelate and decursin.Kor. J. Pharmacogn., 21, 64–68 1990. CAS. We investigated the cellular and molecular mechanisms mediating the effects of Angelica gigas Nakai extract AGNE through the mitogen-activated protein kinases MAPKs/NF- κ B pathway using in vitro and in vivo atopic dermatitis AD models. We examined the effects of AGNE on the expression of proinflammatory cytokines and chemokines in human mast cell line-1 HMC-1 cells.
Abstract. Angelica gigas root cultures were elicited with various elicitors, including yeast extract, chitin, methyl jasmonate, salicylic acid, and copper, with the aim of increasing the production of decursin and decursinol angelate. The treatment of A. gigas root cultures with a combination of yeast extract 2 g l −1 and copper ion 0.5 mM at the late exponential growth phase increased. Abstract: Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to. 1. Chem Pharm Bull Tokyo. 1968 Jun;166:1139-40. Coumarins from the root of Angelica gigas Nakai. Konoshima M, Chi HJ, Hata K. PMID: 5706829.
A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1 H-NMR, and 13 C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C. Material. Decursinol, the single compound extracted from Angelica gigas Nakai was purchased from NPBANK of National Development Institute of Korean Medicine Gyungsan, Korea; its molecular structure is shown in Fig. 1a. By performing HPLC chromatography, its purity was. Angelica gigas Nakai i.e., Korean angelica or Dang Gui is used as a traditional medicinal herb in East Asian countries. Decursin and decursinol angelate are major coumarinic components of the A. gigas root, which has anti-cancer [1–3], neuroprotective , anti-platelet , prevention of obesity  and bone-loss , and anti-inflammatory. Angelica gigas Nakai i.e., Korean angelica or Dang Gui is used as a traditional medicinal herb in East Asian countries. Decursin and decursinol angelate are major coumarinic components of the A. gigas root, which has anti-cancer [1,2,3], neuroprotective , anti-platelet , prevention of obesity  and bone-loss , and anti-inflammatory [8, 9] properties.
Angelica gigas Nakai AGN is an oriental traditional medicine to treat anemia, dysmenorrhea, and migraine. However, its anti-lymphoma effect is yet to be tested. Here, we demonstrated that AGN. Korean Angelica gigas Nakai Umbelliferae family; AGN root and nine other herbs in LNCaP cells. We describe, for the first time, the identification of decursin from AGN as a novel antiandrogen and AR agent. Decursin was first isolated from Angelica decursiva Fr. et Sav. in. Angelica root typically is given at doses of 3 to 6 g/day of the crude root, but clinical trials are lacking regarding dosage recommendations. Contraindications. Crude fruit extract is not recommended; safety and efficacy have not been established. Pregnancy/Lactation. Avoid use.
Angelica gigas Nakai AGNE is a Korean traditional herbal medicine and is one of the most popular herbal medicines used in Asian countries, including Korea, Japan Angelica acutiloba A. acutiloba, and China Angelica sinensis. AGNE has been studied extensively and found to contain various substances, including coumarins. Angelica gigas Nakai root extract INM®-176 Angelica gigas Nikai root extract, also known as dong quai, is a flowering plant native to Asia and a popular medicinal herb in Korea. INM-176 is a patented extract of angelica root. A double-blind, placebo-controlled trial demonstrated INM-176 can help with mild age-related memory problems..
|Korean Angelica gigas Nakai AGN is a major medicinal herb used in Asian countries such as Korea and China. Traditionally, its dried root has been used to treat anemia, pain, infection and articular rheumatism in Korea, most often through boiling in water to prepare the dosage forms.||Aim of the study. The root of Angelica gigas Nakai Korean “Dang-Gui” has been used to treat female afflictions and anemia in traditional oriental herbal medicine since ancient times in Korea. The objective of this study is to identify the anti-cancer mechanism induced by A. gigas extract including decursin and decursinol angelate in human cervical cancer cells for scientific evidence.||Although Danggui is the root of Angelica gigas NAKAI in the Korean Pharmacopoeia, it is determined that Danggui is also the root of Angelica sinensis OLIV. DIELS in China and Hong Kong, as well as the root of Angelica acutiloba KITAGAWA in Japan. Accordingly, we tried to develop an identification method using the main compounds in A. gigas, A. sinensis, and A. acutiloba through HPLC/diode.|
Angelica gigas Nakai AGN belongs to the Umbel-liferae family.5 The root of AGN is one of the most popular herbal medicines used in Asian countries. In Europe and North America, AGN is also marketed as a functional food product. AGN has been studied exten-sively and has been shown to contain coumarins, essen-tial oils, and polyacetylenes. Description from Flora of China. Plants perennial, 1–2 m, stout. Root conic, gray brown, 2–5 cm thick. Stem purplish, ribbed. Basal and lower leaves petiolate, petioles 30–45 cm, sheaths broad; blade triangular-ovate in outline, 20–40 × 20–30 cm, 2–3-ternate-pinnate, basal pinnae petiolulate; leaflets oblong-lanceolate, 4–15 × 1.5–5 cm, base decurrent, margin irregularly. In another study, the roots of Angelica gigas and Angelica acutiloba were collected from the field of Snyder Research and Extension Farm Rutgers University, New Jersey, and analyzed for their essential oil composition. The main constituents of the Angelica gigas root essential oil were ligustilide 47% and γ-terpinene 14%.
Angelica gigas Nakai BE0622A1, one of the 420 natural products, showed the most effective anticancer effect. a The HeLa cells were treated with various concentrations of the indicated natural products for 24 h, and the MTT assay was subsequently performed.b The HeLa cells were treated with various concentrations of BE0622A1, BE1114A1, and BE1197A1 for 24 h, and cell lysates were. Isolation and Purification of Decursin and Decursinol Angelate in Angelica gigas Nakai Article PDF Available in Journal of the Korean Society of Food Science and Nutrition 385:653-656 · May.
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